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  1. The tumor microenvironment (TME) is increasingly acknowledged as a determinant in the malignant transformation and progression of castration-resistant prostate cancer (CRPC). Cancer-associated fibroblasts (CAF...

    Authors: Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu and Qi Hou
    Citation: BMC Cancer 2025 25:813
    Content type: Research Published on:

  2. This study aimed to compare oncological outcomes and complication rates between radical hysterectomy (RH) and concurrent chemoradiotherapy (CCRT) in patients with stage IIICr cervical cancer without parametria...

    Authors: Hee Yeun Yoon, Jong Mi Kim, Yoon Young Jeong, Yoon Hee Lee, Min Ju Kim, Yoon Seok Choi, Jung Min Ryu and Gun Oh Chong
    Citation: BMC Cancer 2025 25:811
    Content type: Research Published on:

  3. Life’s Crucial 9 (LC9) is a recently proposed cardiovascular health (CVH) scoring system that integrates psychological well-being with Life’s Essential 8 (LE8). However, its prognostic value remains unclear. T...

    Authors: Hongyang Gong, Ming Gao and Zhiwen Zeng
    Citation: BMC Cancer 2025 25:805
    Content type: Research Published on:

  5. This study aimed to investigate the incidence of post radiation nasopharyngeal necrosis (PRNN) in primary NPC after intensity modulated radiation therapy (IMRT) and identify the predictors of risk.

    Authors: Xing-Li Yang, Li Lin, Sha-Sha He, Dan-Wan Wen, Jia Kou, Yan Wang, Xue-Cen Wang and Yong Chen
    Citation: BMC Cancer 2025 25:802
    Content type: Research Published on:

  6. Chronic hepatitis B virus (HBV) infection poses a significant global public health challenge and is found closely related to extrahepatic cancers, including head and neck cancer. Oral squamous cell carcinoma (...

    Authors: Rukeng Tan, Yiyao Zhu, Zengyu Chen, Xinkai Feng, Yujie Liang, Sien Zhang, Nuerbiya Abuduxiku, Guiqing Liao and Le Yang
    Citation: BMC Cancer 2025 25:801
    Content type: Research Published on:

  7. Studies on sex-related differences in post-lung cancer surgery symptoms are limited. Understanding these differences may provide insights into patient recovery. Therefore, we investigated sex-related differenc...

    Authors: Jia Liao, Xiaoqun Hu, Xing Wei, Wei Dai, Hongfan Yu, Xin Tian, Yaqin Wang, Qin Qin, Na Xu, Yuanyuan Li, Qiang Li, Qiuling Shi and Xiaoqin Liu
    Citation: BMC Cancer 2025 25:800
    Content type: Research Published on:

  8. While PD-L1 expression serves as a predictive biomarker for programmed cell death 1 and its ligand (PD-1/PD-L1) inhibitor efficacy in patients with non-small cell lung cancer (NSCLC), its association with trea...

    Authors: Qian Zhu, Hao Hu, Li-Ying OuYang, Rong Yang, Wen-Xiao Wei, Pin Huang and Xin-Rong He
    Citation: BMC Cancer 2025 25:799
    Content type: Research Published on:

  9. The breast cancer recurrence and chemoresistance has increased over the years. A novel PKC, PKCε, may promote chemoresistance by causing hypoxia and cancer metabolic rewiring. A natural flavonoid, Zapotin, in ...

    Authors: Khushbukhat Khan, Maryam Anwar, Yasmin Badshah, Naeem Mahmood Ashraf, Arslan Hamid, Janeen H. Trembley, Maria Shabbir, Tayyaba Afsar, Fohad Mabood Husain, Dilawar Khan and Suhail Razak
    Citation: BMC Cancer 2025 25:798
    Content type: Research Published on:

  10. Liver hepatocellular carcinoma (LIHC) often has a poor prognosis. Since the relationship between HRas proto-oncogene, GTPase (HRAS) and LIHC has not been elucidated, the aim of this study was to explore the me...

    Authors: Xingbao Fang, Yan Cai, Zhuoyu Zhao, Shaohua Yang, Zhaojun Li, Xiongbing Peng, Meifang Hang, Peiwan Liu and Yuehong Li
    Citation: BMC Cancer 2025 25:797
    Content type: Research Published on:

  11. Lymphovascular space invasion (LVSI), a prognostic indicator closely associated with tumour invasiveness, lymph node metastasis risk, and recurrence rate, is crucial in endometrial cancer (EC) staging; however...

    Authors: Wenwen Ma, Weijing Meng, Jinfeng Yin, Jie Liang, Xizhen Wang, Jingang Liu and Fuyan Shi
    Citation: BMC Cancer 2025 25:796
    Content type: Research Published on:

  13. Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. However, whether mitochondrial traits causally affect cancer risk remains unclear. This stud...

    Authors: Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng and Puhua Zeng
    Citation: BMC Cancer 2025 25:794
    Content type: Research Published on:

  14. Lymphovascular invasion (LVI) is associated with poor prognosis in a variety of malignancies; however, its prognostic value has not been fully defined in patients with colorectal cancer with liver metastases (...

    Authors: Wei Li, Bo Liu, Xingxing Xiang, Qun Zhang, Qinglin Yang, Yinghao Cao and Tao Liu
    Citation: BMC Cancer 2025 25:793
    Content type: Research Published on:

  15. In Uganda, colorectal cancer (CRC) is steadily increasing according to the Kampala Cancer Registry. In the West, microsatellite instability is detected in 90% of hereditary nonpolyposis colon cancers (HNPCC) w...

    Authors: Richard Wismayer, Rosie Matthews, Celina Whalley, Julius Kiwanuka, Fredrick Elishama Kakembo, Steve Thorn, Henry Wabinga, Michael Odida and Ian Tomlinson
    Citation: BMC Cancer 2025 25:792
    Content type: Research Published on:

  16. To investigate the correlation between thyroid dysfunction (TD) and the efficacy of programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors in the treatment of advanced lung can...

    Authors: Yanling Wang, Xiaoping Ma, Jia Ma, Jing Li, Zhiyi Lin, Wei Gao, Ping Gong and Ping Dai
    Citation: BMC Cancer 2025 25:791
    Content type: Research Published on:

  17. Diabetes is associated with impaired breast cancer prognosis; however, the effectiveness of glycosylated hemoglobin (HbA1c) as a prognostic biomarker in breast cancer remains uncertain, especially for patients wi...

    Authors: Jonas Busk Holm, Jens Meldgaard Bruun, Peer Christiansen, Reimar Wernich Thomsen, Jan Frystyk, Deirdre Cronin-Fenton and Signe Borgquist
    Citation: BMC Cancer 2025 25:790
    Content type: Research Published on:

  18. ATPase H+ transporting V0 subunit b (ATP6V0B) is an essential component of the vacuolar ATP multi-protein complex (V-ATPase) associated with energy metabolism. However, information on its role and mechanism of ac...

    Authors: Xinsheng Wang, Yanqing Qu, Yanbo Sun, Tong Yang, Wei Wang, Xinmeng Dou and Yong Jia
    Citation: BMC Cancer 2025 25:789
    Content type: Research Published on:

  19. Cholangiocyte phenotype hepatocellular carcinoma (HCC) is highly invasive. This study aims to develop and validate an optimal machine learning model to predict cholangiocyte phenotype HCC based on T1 mapping g...

    Authors: Wei Liu, Zhiping Cai, Yifan Chen, Xingqun Guan, Jieying Feng, Haixiong Chen, Baoliang Guo, Fusheng OuYang, Chun Luo, Rong Zhang, Xinjie Chen, Xiaohong Li, Cuiru Zhou, Shaomin Yang, Ziwei Liu and Qiugen Hu
    Citation: BMC Cancer 2025 25:788
    Content type: Research Published on:

  20. The role of autologous hematopoietic stem cell transplantation (AHSCT) in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph-ALL) remains controversial. The aim of this retrospective...

    Authors: Ryszard Swoboda, Myriam Labopin, Sebastian Giebel, Johan Maertens, Elena Parovichnikova, Jurjen Versluis, Jiri Pavlu, Anna Kopinska, Saveria Capria, Ludek Raida, Alessandro Rambaldi, Denis Caillot, Frantisek Folber, David Nachbaur, Mustafa Ozturk, Mahmoud Aljurf…
    Citation: BMC Cancer 2025 25:787
    Content type: Research Published on:

  22. To explore the diagnostic performance and feasibility of high-frame-rate contrast-enhanced ultrasound (HFR CEUS) combined with contrast vector imaging (CVI) in detecting benign and malignant superficial lymph ...

    Authors: Ruiying Li, Xiaofeng Lan, Xiang Xie, Jun Wu, Rui Hu and Jiale Guo
    Citation: BMC Cancer 2025 25:785
    Content type: Research Published on:

  23. Many prognostic scores based on systemic inflammation have been developed. Most of these prognostic scores have been shown to influence the prognosis of hepatocellular carcinoma (HCC) patients. This research a...

    Authors: Shao-Long Lu, Qing-Yuan Zhang, Yuan-Quan Zhao, Hua-Lin Wu, Jie Lin, Peng Zhu, Zheng-Jun Qin, Xiao-Bo Wang and Jie Chen
    Citation: BMC Cancer 2025 25:784
    Content type: Research Published on:

  24. Chordin-like 1 (CHRDL1) is a secreted antagonist of bone morphogenetic proteins, and has been implicated in various biological processes and cancer prognosis. This study offered a detailed examination of CHRDL1 e...

    Authors: Guangyin Ou, Tangke Gao, Shaopu Hu, Shuixiu Zhang, Shuo Song, Yue Sun, Ying Wang, Ruikang Zhong, Kaiwen Hu, Lei Gao and Min Jiang
    Citation: BMC Cancer 2025 25:783
    Content type: Research Published on:

  25. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis and limited treatment options. Autophagy targeting plays a complex role in tumor resistance. The role of long ...

    Authors: Linlei Zhang, Sainan Li, Jiajie Shi, Hao Guo, Bo Wang and Cuizhi Geng
    Citation: BMC Cancer 2025 25:782
    Content type: Research Published on:

  26. The potential links between triglyceride-glucose (TyG) related indicators and breast cancer incidence after menopause have been less well studied, and the joint associations between genetic risk, TyG related i...

    Authors: Zhen Li, Zengle Zhao, Tongchao Zhang, Xiaorong Yang, Hao Chen, Xiaolin Yin, Hao Bai, Xinjie Liu, Tongmin Chang, Yuan Zhang and Ming Lu
    Citation: BMC Cancer 2025 25:781
    Content type: Research Published on:

  27. This study aimed to classify dysplastic and healthy oral epithelial histopathological images, according to WHO and binary grading systems, using the Vision Transformer (ViT) deep learning algorithm—a state-of-...

    Authors: Mahdi Hadilou, Nazanin Mahdavi, Elham Keykha, Ali Ghofrani, Elahe Tahmasebi and Masoud Arabfard
    Citation: BMC Cancer 2025 25:780
    Content type: Research Published on:

  28. Hepatocellular carcinoma (HCC) frequently recurs after surgical treatment, necessitating effective postoperative recurrence management for improved long-term patient outcomes. Currently, no standardized treatm...

    Authors: Wei Deng, Jin Xie, Tao Wang, Laihui Luo, Guoqing Zhu, Yongqiang Xiao, Jiahao Tao, Liucong Lin, Xian Ge, Wu Wen, Minglong Wang, Bin Yu, Yu Liu, Rongguang Luo, Renhua Wan, Zhigao Hu…
    Citation: BMC Cancer 2025 25:779
    Content type: Research Published on:

  29. Every year, almost 900.000 people are diagnosed with head and neck cancer (HNC) worldwide. HNC contains many different subsites and a large variability in tumor biology. This often results in small and/or hete...

    Authors: Arta Hoesseini, Emilie A. C. Dronkers, Eveline Dieleman, Maria J. De Herdt, Marjan. H. Wieringa, Marie-Louise F. van Velthuysen, Marinella P. J. Offerman, Aniel Sewnaik, Dominiek Monserez, Stijn Keereweer, Jose A. U. Hardillo and Robert Jan Baatenburg de Jong
    Citation: BMC Cancer 2025 25:778
    Content type: Research Published on:

  30. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies, characterized by high heterogeneity and poor outcomes. Effective classification for patient stratification and identifying reli...

    Authors: Xiuzhi Zhang, Zhi Wang, Yutong Zhao, Hua Ye, Tiandong Li, Han Wang, Guiying Sun, Feifei Liang, Liping Dai, Peng Wang and Xiaoli Liu
    Citation: BMC Cancer 2025 25:777
    Content type: Research Published on:

  31. Gastric cancer is a common malignant tumor, and radical gastrectomy can markedly improve the prognosis of gastric cancer patients. However, some patients are diagnosed with advanced gastric cancer before recei...

    Authors: Gan Liu, Shougen Cao, Xiaodong Liu, Yulong Tian, Wenbin Yu, Jie Chai, Leping Li, Xixun Wang, Xianqun Chu, Quanhong Duan, Jianjun Qu, Hao Wang, Huanhu Zhang, Xinjian Wang, Xizeng Hui, Daogui Yang…
    Citation: BMC Cancer 2025 25:776
    Content type: Study Protocol Published on:

  32. The myocyte enhancer factor-2 (MEF2) family genes were involved in the carcinogenesis and prognosis of multiple human tumors. The impact of MEF2s on the occurrences, progression, and clinical outcome of pancre...

    Authors: Chunxia Zhai, Xiaorong Ding, Liping Mao, Yang Ge, Anqi Huang, Fan Yang and Yi Ding
    Citation: BMC Cancer 2025 25:775
    Content type: Research Published on:

  33. Colorectal cancer (CRC) is a multifactorial and age-related disease. Additionally, age, sex, and risk factors for developing CRC may include genetic, epigenetic, and immunologic characteristics and lifestyle h...

    Authors: Nino Chigvinadze, Ia Pantsulaia, Teimuraz Lejava, Archil Aladashvili, Tsitsino Atamashvili, Nino Khvichia and Khatuna Rekhviashvili
    Citation: BMC Cancer 2025 25:774
    Content type: Research Published on:

  34. Head and neck squamous cell carcinoma (HNSCC) treatment faces significant clinical challenges. Lactate metabolism plays a crucial role in the initiation of many cancers and the tumor microenvironment (TME). Ho...

    Authors: Xiaochuan Chen, Zhangying Jiang, Junping Pan, Wenqian Xu, Ying Li, Xin Chen, Yuhui Pan, Youliang Weng, Dan Hu and Sufang Qiu
    Citation: BMC Cancer 2025 25:773
    Content type: Research Published on:

  36. Myeloid-derived suppressor cells (MDSCs) are a subset of immature myeloid cells with immunosuppressive properties. Evidence suggests that abnormal immune system can lead to immune dysfunction and increase the ...

    Authors: Jingru Liu, Shucheng Chen, Yanrong Huang, Kaiming Xu, Maoqing Tan, Wei Dai, Xiaoting Wang, Diyu Hou, Shuxia Zhang, Jiadi Chen and Huifang Huang
    Citation: BMC Cancer 2025 25:771
    Content type: Research Published on:

  37. Most of the landmark cohorts and reviews that assessed the psychosocial outcomes among adolescent and young adult (AYA) cancer survivors have focused on Western populations. This scoping review summarizes the ...

    Authors: Yihui Wei, Panpan Xiao, Weishang Deng, Cho Lee Wong, Chun-Kit Ngan, Winnie Wan-Yee Tso, Alex Wing-Kwan Leung, Herbert Ho-Fung Loong, Chi Kong Li, Alexandre Chan and Yin Ting Cheung
    Citation: BMC Cancer 2025 25:770
    Content type: Systematic Review Published on:

  38. Prostate cancer is one of the most prevalent malignancies in men. Once prostate cancer advances to castration-resistant prostate cancer (CRPC), the 5-year survival rate can decrease to as low as 14 months. How...

    Authors: Na Wang, Xinzhi Xu, Yizhe Zhong, Yujie Wan, Ruixia Hong, Qizhi Wang, Jia Tang, Jiaqi Gong, Hang Zhou and Fang Li
    Citation: BMC Cancer 2025 25:769
    Content type: Research Published on:

  39. Metastatic prostate cancer is commonly treated with androgen deprivation therapy (ADT) and chemotherapy, which often leads to treatment resistance and disease progression with limited effective interventions. ...

    Authors: Zhiguo Fan, Duocai Li, Shi Yan, Xianzhi Zhao, Lei Yin, Weidong Xu, Ye Wang, Huojun Zhang, Yifan Chang and Shancheng Ren
    Citation: BMC Cancer 2025 25:768
    Content type: Study Protocol Published on:

  40. Lung cancer (LC) is a leading cause of cancer-related mortality worldwide. The combination of immune checkpoint inhibitors (ICIs) with chemotherapy significantly extends survival but increases the risk of trea...

    Authors: Shun Li, Zhifei Huang, Xiaoyu Zhong, Yan Zhou and Hao Jiang
    Citation: BMC Cancer 2025 25:767
    Content type: Research Published on:

  41. Small cell carcinoma (SmCC) of the bladder is a rare and aggressive malignancy. Characterizing transcription factor (TF)-defined subtypes may provide insights into its biology and inform targeted therapies. Th...

    Authors: Keiichiro Kitahama, Yasuyuki Shigematsu, Emiko Sugawara, Mahmut Amori, Gulanbar Amori, Rumiko Saito, Akihiro Ohmoto, Junji Yonese, Kengo Takeuchi and Kentaro Inamura
    Citation: BMC Cancer 2025 25:766
    Content type: Research Published on:

  42. Consistency between malnutrition defined by Global Leadership Initiative on Malnutrition (GLIM) and Patient-Generated Subjective Global Assessment (PG-SGA) has not been thoroughly elucidated in patients with c...

    Authors: Jielin Zhou, Shoumei Yang, Ting Liu, Yubei Sun and Suyi Li
    Citation: BMC Cancer 2025 25:765
    Content type: Systematic Review Published on:

  43. The nuclear receptor liver receptor homolog 1 (LRH1)/NR5A2 is aberrantly expressed in diverse cancer types, including liver and lung cancers. Since we previously showed that excessive phosphorylation of human ...

    Authors: Hayato Mine, Kotaro Sugimoto, Makoto Kobayashi, Hironori Takagi, Naoyuki Okabe, Satoshi Muto, Yasuyuki Kobayashi, Yuko Hashimoto, Hiroyuki Suzuki and Hideki Chiba
    Citation: BMC Cancer 2025 25:764
    Content type: Research Published on:

  45. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and most often diagnosed at an advanced stage. Identification of markers for the early diagnosis of PDAC is crucial. In this study...

    Authors: Jong-chan Lee, Sung Won Kang, Eun-Jin Sim, Jin-Sik Bae, Seong-mo Koo, Mun-sub Byoun, Serin Kwon, Seoi Hong, Yunji Kim, Yuna Youn, Kwangrok Jung, Jaihwan Kim, Hyoung Hwa Jeong, Jihie Kim and Jin-Hyeok Hwang
    Citation: BMC Cancer 2025 25:762
    Content type: Research Published on:

  46. Although research has highlighted the link between anxiety and cancer, studies on the relationship between the two have produced inconsistent findings. Therefore, we investigated this relationship and also exa...

    Authors: Sang-Hue Yen, Yi-Hsuan Hsu, Doreen Phiri, Chia-Chun Kuo, Hui-Fen Fang and Min-Huey Chung
    Citation: BMC Cancer 2025 25:761
    Content type: Research Published on:

  47. Postoperative chemotherapy is an essential treatment in locally advanced colon cancer, however, effective biomarkers for predicting patients who will benefit from this therapy are lacking. This study aims to e...

    Authors: Lu Lu, Huan Li, Hongfang Yin, Feng Wang, Xiaowen Sun, Yanyun Chang, Yuling Sheng, Qi Liu, Yifan Peng and Changzheng Du
    Citation: BMC Cancer 2025 25:760
    Content type: Research Published on:

  48. Malignant spinal cord compression (MSCC) can lead to immediate neurological impairment. In order to preserve and, optimally, restore neurological functions, urgent treatment (usually, within 24 h) is necessary...

    Authors: Manuel Guhlich, Teresa Esther Maag, Markus Anton Schirmer, Tatiana Andrea Chacón Quesada, Dorothee Mielke, Stefan Rieken, Martin Leu and Leif Hendrik Dröge
    Citation: BMC Cancer 2025 25:759
    Content type: Research Published on:

  49. Fixed focal fluorine 18 fluorodeoxyglucose (18F-FDG) uptake in colorectal areas is commonly seen in PET/CT scan and may indicates malignant tumor. This study aims to investigate the diagnostic efficacy of dual-ti...

    Authors: Baosheng Meng, Yuanyuan Ma, Yuetao Wang, Mingge Zhou and Chen He
    Citation: BMC Cancer 2025 25:755
    Content type: Research Published on:

  50. The response rate of antibody therapy targeting immune checkpoint molecules in ovarian cancer is insufficient. This study aimed to develop a novel gene immunotherapy model targeting programmed death ligand 1 (...

    Authors: Tamaki Yahata, Saori Toujima, Izumi Sasaki, Naoyuki Iwahashi, Megumi Fujino, Kaho Nishioka, Tomoko Noguchi, Yuko Tanizaki-Horiuchi, Tsuneyasu Kaisho and Kazuhiko Ino
    Citation: BMC Cancer 2025 25:749
    Content type: Research Published on:

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