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  1. LUAD patients with EGFR exon 20 insertions (ex20ins) have a poorer prognosis than those with EGFR 19del or L858R mutations. The FAVOUR study showed high-dose furmonertinib’s efficacy in ex20ins patients. Howev...

    Authors: Sen Yang, Yang Liu, Jiuzhou Zhao, Zhen He, Haiyang Chen, Shuxiang Ma, Yingxi Wu, Yufeng Wu, Lili Wang, Cuicui Zhang and Qiming Wang
    Citation: BMC Cancer 2025 25:900
    Content type: Research Published on:

  3. Colorectal cancer (CRC) is the leading cause of cancer-related death in Puerto Rico, posing significant challenges for patients with multiple chronic conditions (MCC). This qualitative study aimed to explore o...

    Authors: Maira A. Castañeda-Avila, Daniela Latoni-Guillermety, Meagan Sabatino, Karen J. Ortiz-Ortiz and Kate L. Lapane
    Citation: BMC Cancer 2025 25:898
    Content type: Research Published on:

  4. People with HIV (PWH) are less likely to receive cancer treatment compared to those without HIV. Social factors, such as cancer treatment facility type, which may impact cancer treatment receipt among PWH have...

    Authors: Jessica Y. Islam, Yi Guo, Jennifer K. McGee-Avila, Kea Turner, Amir Alishahi Tabriz, Yu Chen Lin, Susan T. Vadaparampil, Anna E. Coghill, Marlene Camacho-Rivera and Gita Suneja
    Citation: BMC Cancer 2025 25:897
    Content type: Research Published on:

  5. Micro-photodynamic therapy (MWPDT) combines photo-dynamic (PDT) and microwave-dynamic (MWDT) therapies with sensitizers, offers new avenues for cancer treatment. Despite the fact that novel sensitizers for MWP...

    Authors: Samir Ali Abd El-Kaream, Nasser Ali Mohamed Hassan, Hassan Saleh Abdullatif Saleh, Mohamed Albahloul Salem Albahloul, Abdalla Mohamed Khedr and Sohier Mahmoud El-Kholey
    Citation: BMC Cancer 2025 25:896
    Content type: Research Published on:

  6. Hepatocellular Carcinoma (HCC) is related to dysregulated lipid metabolism and immunosuppressive microenvironment. This study developed a genetic risk model using lipid metabolism-related genes to predict surv...

    Authors: Lei Xu, Ting Xiao, Tengfei Chao, Huihua Xiong and Wei Yao
    Citation: BMC Cancer 2025 25:895
    Content type: Research Published on:

  7. Venetoclax with hypomethylating agents (VEN-HMAs) has shown inconsistent efficacy versus induction chemotherapy (IC) in newly diagnosed AML (ND-AML). Whether or not VEN-HMAs are of clinical benefit remains unc...

    Authors: Yun Liu, Ying Zhang, Jinhong Gao, Lijuan Wang, Fang Xie, Chengtao Zhang, Peimin Mao and Jinsong Yan
    Citation: BMC Cancer 2025 25:894
    Content type: Systematic Review Published on:

  8. Breast cancer remains the most diagnosed cancer among women world-wide and a leading cause of cancer-related deaths accounting for 15% of deaths in 2018. Worldwide, the incidence increased from 1.4 million in ...

    Authors: Andrew Khulekani Ndlovu, Ishmael Kasvosve, Patricia S. Rantshabeng, Kirthana Sharma, Dhiren Govender and Richard Naidoo
    Citation: BMC Cancer 2025 25:893
    Content type: Research Published on:

  9. Neuroblastoma, developed from the sympathetic nervous system, is a deadly childhood malignancy. There is an urgent need to elucidate its intricated etiology. MYCN amplification leads to aggressive neuroblastoma a...

    Authors: Jiabin Liu, Mengzhen Zhang, Yu Ouyang, Jiaming Chang, Wenli Zhang, Chunlei Zhou, Jing He and Xinxin Zhang
    Citation: BMC Cancer 2025 25:892
    Content type: Research Published on:

  10. This study aimed to analyze the trends and epidemiological characteristics of pancreatic cancer (PC) mortality in China from 2004 to 2021, focusing on gender, age, and regional disparities. The goal was to pro...

    Authors: Rui He, Zhengnan Shen, Qiuping Chen, Haiyang Hu, Xin Ding, Zhenglong Zheng, Quansheng Feng and Baixue Li
    Citation: BMC Cancer 2025 25:891
    Content type: Research Published on:

  11. The aim of this study is to interrogate the gross histopathological patterns, correlation between histological type with tumor location, treatment, and complications of patients with ameloblastomas seen at Kha...

    Authors: Saba Eltayeb Mohammed Ahmed, Nourelhoda Alim, Fatema Akhter, Tahsinul Haque, Mohamed Abdelwahab Higzi, Raghad Abdullah Altassan, Aseel Tariq Aboaljadayel, Mohammed Saad Alqarni, Sally Elhaddad, Tasnia Habib, Turki Thaar AlQahtani, Nuha Abdalla Osman Mustafa and Abdullah Alanazi
    Citation: BMC Cancer 2025 25:890
    Content type: Research Published on:

  12. Breast cancer surgery is a critical intervention with potentially significant psychological impacts. This systematic review and meta-analysis investigate the effect of different surgical approaches on levels o...

    Authors: Fatemeh Movahed, Masoud Dehbozorgi, Saba Goodarzi, Fatemeh Esmaeilpur Abianeh, Razman Arabzadeh Bahri and Arman Shafiee
    Citation: BMC Cancer 2025 25:889
    Content type: Systematic Review Published on:

  13. This study aims to develop and validate a novel radiomics model utilizing magnetic resonance imaging (MRI) to predict progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHC...

    Authors: Xuni Xu, Xue Jiang, Haoran Jiang, Xiaoye Yuan, Mengjing Zhao, Yuqi Wang, Gang Chen, Gang Li and Yuxia Duan
    Citation: BMC Cancer 2025 25:888
    Content type: Research Published on:

  15. Breast cancer classify into four molecular subtypes: Luminal A, Luminal B, HER2-overexpressing (HER2), and triple-negative (TNBC) based on immunohistochemical assessments. The multimodal ultrasound features co...

    Authors: Hui Li, Chang-tao Zhang, Hua-guo Shao, Lin Pan, Zhongyun Li, Min Wang and Shi-hao Xu
    Citation: BMC Cancer 2025 25:886
    Content type: Research Published on:

  16. HPV integration is a crucial genetic step in cervical carcinogenesis and the level of HPV integration increases with the grade of precancerous lesion. This study aimed to conduct risk stratification based on H...

    Authors: Kexin Li, Fanwei Huang, Tao Zhang, Fan Yang, Weitao Duan, Shimin Chen, Ting Hu and Xiaoyuan Huang
    Citation: BMC Cancer 2025 25:885
    Content type: Research Published on:

  17. Acute leukemia is an aggressive, highly heterogeneous hematological malignancy. A Disintegrin And Metalloproteinase Domain-6 (ADAM6), a member of ADAMs family, has emerged recently as a potential novel player ...

    Authors: Heba M. Anis, Nahed M. Rakha, Dina H. Kassem and Amany M. Kamal
    Citation: BMC Cancer 2025 25:884
    Content type: Research Published on:

  18. Patients undergoing surgery for endometrial intraepithelial neoplasia (EIN) have a high likelihood of concurrent endometrial cancer (EC). Lymph node dissection (LND) may be required during the operation. Our a...

    Authors: Neçirvan Çağdaş Çaltek, Hale Özer Çaltek, Mahmut Yassa, Gazi Güner, İlteriş Yaman and İlkbal Temel Yüksel
    Citation: BMC Cancer 2025 25:883
    Content type: Research Published on:

  19. To explore the efficacy and safety of RALOX-HAIC (raltitrexed plus oxaliplatin) combined with lenvatinib in the treatment of elderly patients with unresectable hepatocellular carcinoma (uHCC), aiming to provid...

    Authors: Haohao Lu, Ya Gao, Xiangwen Xia, Qing Fu and Dongqiao Xiang
    Citation: BMC Cancer 2025 25:882
    Content type: Research Published on:

  20. Post-hepatectomy liver failure (PHLF) is one of the major complications following hepatectomy for hepatocellular carcinoma (HCC). Early identification and precise prediction of PHLF are essential for effective...

    Authors: Tianyi Liang, Yongfei He, Shutian Mo, Yuan Liao, Ketuan Huang, Qiang Gao, Xiaoqiang Shen, Chengkun Yang, Xiwen Liao, Wei Qin, Guangzhi Zhu, Hao Su, Xinping Ye, Chuangye Han and Tao Peng
    Citation: BMC Cancer 2025 25:881
    Content type: Research Published on:

  21. Meibomian Gland Carcinoma (MGC) is a highly malignant eyelid tumor with a poor prognosis. This study investigates the molecular mechanisms underlying MGC, focusing on the abnormal expression of E2F transcripti...

    Authors: Wei Wang, Hetong Wang, Xun Liu, Fei Xu, Qin Tang, Chuanli Zhang, Jiaqi Lin, Limin Zhu and Tingting Lin
    Citation: BMC Cancer 2025 25:880
    Content type: Research Published on:

  22. The objective of this study is to quantify abdominal obesity markers from computed tomography (CT) scans at primary diagnosis and follow-up in a large endometrial cancer cohort, and to assess temporal change i...

    Authors: Kristine E. Fasmer, Jostein Sæterstøl, Maria B. S. Ljunggren, Astrid M. K. Brun, Johanna M. A. Pijnenborg, Kathrine Woie, Camilla Krakstad and Ingfrid S. Haldorsen
    Citation: BMC Cancer 2025 25:879
    Content type: Research Published on:

  23. This study aimed to evaluate the efficacy and safety of selinexor-based regimens as first-line treatments for elderly patients with diffuse large B-cell lymphoma (DLBCL).

    Authors: Jing Li, Jingjing Ge, Tingting Chen, Jianghua Cao, Xiaohua He, Shulan Wang, Hang Yang, Yu Wang, Peng Sun, Jiajia Huang, Shan Liu and Zhiming Li
    Citation: BMC Cancer 2025 25:878
    Content type: Research Published on:

  24. The pathogenesis of CRC requires primary genetic and epigenetic mechanisms including, methylation of CpG islands of the genes. In the current study, micro RNA-139-5p (miR-139-5p) promoter methylated DNA was evalu...

    Authors: Masoud Asefi, Nayebali Rezvani, Massoud Saidijam, Ali Reza Soltanian, Ali Reza Khalilian and Ali Mahdavinezhad
    Citation: BMC Cancer 2025 25:877
    Content type: Research Published on:

  25. This article has been retracted. Please see the Retraction Notice for more detail: https://doiorg.publicaciones.saludcastillayleon.es/10.1186/s12885-015-1032-4.

    Authors: Luiz Gustavo A. Chuffa, Beatriz A. Fioruci-Fontanelli, Leonardo O. Mendes, Fábio R. Ferreira Seiva, Marcelo Martinez, Wagner J. Fávaro, Raquel F. Domeniconi, Patrícia F. F. Pinheiro, Lucilene Delazari dos Santos and Francisco Eduardo Martinez
    Citation: BMC Cancer 2025 25:876
    Content type: Retraction Note Published on:

  26. The effect of statin use on hepatocellular carcinoma (HCC) in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) or type two diabetes mellitus (T2DM) is still unclear. In this umbre...

    Authors: Nazanin Hosseinkhan, Laily Najafi, Soodeh Jahangiri, Zahra Emami and Mohammad E. Khamseh
    Citation: BMC Cancer 2025 25:875
    Content type: Systematic Review Published on:

  27. The exploration of biomarkers is of crucial importance for the prognosis of cancer patients. The objective of this study was to ascertain the predictive value of positron emission tomography (PET) image-derive...

    Authors: Cheng Zheng, Jiangfeng Miao, LiuWei Xu, Yujie Cai, BingShu Zheng, ZhongHua Tan and ChunFeng Sun
    Citation: BMC Cancer 2025 25:874
    Content type: Research Published on:

  28. Multiple Myeloma (MM) is a plasma cell malignancy associated with systemic and renal complications. This study evaluates the prognostic and diagnostic significance of poliovirus receptor (PVR) gene expression ...

    Authors: Eman M. Habib, Asmaa M. Hasan, Sara A. A. Mohammed, Amira A. A. Othman, Rasha Elgamal and Dalia E. Sherief
    Citation: BMC Cancer 2025 25:873
    Content type: Research Published on:

  29. Currently, risk stratification and effective management of heterogeneous patients with cancer based on patient-reported outcomes (PROs), used to evaluate clinical efficacy and outcomes, are relatively rare and...

    Authors: Xiaojuan Hu, Zhihui Duan, Xiaokun Li, Hongyan Cao, Hui Zhao and Yanbo Zhang
    Citation: BMC Cancer 2025 25:872
    Content type: Research Published on:

  30. Insomnia is highly prevalent among cancer survivors. Meta-analyses examining the effects of cognitive-behavioral therapy for insomnia (CBT-I) among cancer survivors have focused on within-group (pre-to-post-in...

    Authors: Joshua T. Cooper, Ellie Svoboda, Allan V. Prochazka and Duc M. Ha
    Citation: BMC Cancer 2025 25:871
    Content type: Systematic Review Published on:

  31. Anaplastic thyroid cancer (ATC) is a markedly invasive subtype of thyroid cancer with a poor prognosis. The Gynostemma pentaphyllum-derived Gypenoside LI (Gyp LI) can inhibit the growth and metastasis of various ...

    Authors: Meiyu Liu, Haidong Liao, Qin Peng, Junwei Huang, Weixiang Liu, Mengqiao Dai, Zanbing Li, Yang Xie, Jiafeng Liu, Yong Ying and Xiangtai Zeng
    Citation: BMC Cancer 2025 25:870
    Content type: Research Published on:

  32. Usual walking pace represents a practical indicator of overall health. However, its association with cancer development remains unexplored. We investigated the relation between self-reported walking pace and c...

    Authors: Michael J. Stein, Hansjörg Baurecht, Patricia Bohmann, Pietro Ferrari, Béatrice Fervers, Emma Fontvieille, Heinz Freisling, Christine M. Friedenreich, Marc J. Gunter, Laia Peruchet-Noray, Anja M. Sedlmeier, Andrea Weber, Michael F. Leitzmann and Julian Konzok
    Citation: BMC Cancer 2025 25:869
    Content type: Research Published on:

  33. Muscle invasive bladder cancer (MIBC) is a malignancy with high recurrence and metastasis rate. Radical cystectomy and lymph node dissection are the current standard cares for MIBC. The demand for bladder pres...

    Authors: Tianhang Lan, Yingying Zhu, Wenlong Zhong, Qihong Tan, Tianxin Lin, Jian Huang and Wang He
    Citation: BMC Cancer 2025 25:868
    Content type: Study Protocol Published on:

  34. Microvascular invasion (MVI) has been recognized as a risk factor for early recurrence after hepatectomy in patients with hepatocellular carcinoma (HCC). This study aimed to estimate the performance of an ultr...

    Authors: Zheyue Shu, Ting Ye, Wei Wu, Menghan Su, Jingcheng Wang, Min Zhang, Ziliang Qian, Haifen Huang, Shusen Zheng and Qi Xia
    Citation: BMC Cancer 2025 25:867
    Content type: Research Published on:

  35. The practice of omitting of axillary lymph node dissection (ALND) in patients with a low tumor burden in sentinel lymph nodes (SLN) has become standard in managing early-stage breast cancer. This study aims to...

    Authors: Yongjin Lu, Zhiqiang Shi, Qiuchen Zhao, Zhao Bi, Xiao Sun, Chunjian Wang, Ruijie Jia, Junsheng Zheng, Jing Sun, Yongsheng Wang and Pengfei Qiu
    Citation: BMC Cancer 2025 25:866
    Content type: Research Published on:

  37. There is increasing interest in using Patient Reported Outcome Measures (PROMs) to provide evidence of how a haematopoietic stem cell transplant (HCT) affects blood cancer patients’ long-term quality-of-life (...

    Authors: Gemma Pugh, Lauren Young, Christina Yiallouridou, Dawn Hart, Karen Dean and Robert Danby
    Citation: BMC Cancer 2025 25:864
    Content type: Research Published on:

  38. This meta-analysis systematically evaluated the effectiveness and safety of immune checkpoint inhibitors (ICIs) in treating advanced cervical cancer, emphasizing their potential as transformative therapeutic o...

    Authors: Zheng-rui Li, Yu-Feng Wang, Chen- Rong Zuo, Jing-Sheng Men, Xin-Yuan Li, Peng Luo, Xiao-San Su and Rui-Fen Sun
    Citation: BMC Cancer 2025 25:863
    Content type: Research Published on:

  39. This study assessed the safety and efficacy of rechallenging patients in advanced non-small cell lung cancer (NSCLC) without targetable driver mutations using a combination of immune checkpoint inhibitors (ICI...

    Authors: Xinrong Chen, Ke Wang, Yongxin Liao, Chuangjie Zheng, Deyu Yang, Zhichao Li and Linzhu Zhai
    Citation: BMC Cancer 2025 25:862
    Content type: Research Published on:

  40. Although inequality in the prevalence and mortality of metastatic breast cancer (mBC) have been documented, the contribution of non-clinical predictors along the care continuum remains unclear. This study aime...

    Authors: Carolyn Brown, Hyeun Ah Kang, Michael Johnsrud, Jamie Terry, Gury Doshi, Stephanie Broussard and Chinelo Orji
    Citation: BMC Cancer 2025 25:861
    Content type: Research Published on:

  41. Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer cell types. We synthesized optimized niosome NPs (NPs) with hi...

    Authors: Nadia Zargarani, Mahsa Kavousi and Elahe Aliasgari
    Citation: BMC Cancer 2025 25:860
    Content type: Research Published on:

  42. Cuproptosis, a novel form of regulatory cell death, was investigated in this study for its effects on cuproptosis-associated proteins during gliomas development, offering novel insights into the mechanism of c...

    Authors: Yu Wang, Sen Qiao, Ping Wang, Mi Li, Xiaozhen Ma, Hongmei Wang and Junhong Dong
    Citation: BMC Cancer 2025 25:859
    Content type: Research Published on:

  43. The role of postoperative radiotherapy (PORT) for patients with completely resected stage III-pN2 non-small-cell lung cancer (NSCLC) remains controversial. PORT is not routinely recommended for patients with c...

    Authors: Jinquan Yao, Yuxin Geng, Junhao Xu, Bingwen Zou and Feifei Teng
    Citation: BMC Cancer 2025 25:858
    Content type: Research Published on:

  44. Transcriptomic and metabolic profiles of tumor cells and stromal cells in oral squamous cell carcinoma (OSCC)-derived from oral submucosal fibrosis (OSF) (ODSCC) have been reported. However, the complex interc...

    Authors: Simin Zhao, Yu Zhang, Xiaoqin Meng, Ye Wang, Yahui Li, Hao Li, Xingyu Zhao, Pishan Yang, Shaopeng Liu and Chengzhe Yang
    Citation: BMC Cancer 2025 25:857
    Content type: Research Published on:

  45. At times of cancer, also family members may need support from healthcare professionals. For support to be relevant it needs to be tailored to a person’s needs. Tailored support is recognized as support co-crea...

    Authors: Maria Samuelsson, Kristina Edman, Merita Neziraj and Anna Ericsson
    Citation: BMC Cancer 2025 25:856
    Content type: Research Published on:

  46. The Child–Pugh (CP) score is widely used to evaluate the severity of liver dysfunction in patients with hepatocellular carcinoma (HCC). Recently, both the albumin-bilirubin (ALBI) and platelet-albumin-bilirubi...

    Authors: Haojie Yang, Shuang Shen, Yuting Yang, Houping Zhou and Bangde Xiang
    Citation: BMC Cancer 2025 25:855
    Content type: Research Published on:

  47. This prospective study examined whether 18F-AlF-NOTA-fibroblast activation protein inhibitor (FAPI)-04 (denoted as 18F-FAPI-04) positron emission tomography/computed tomography (PET/CT) can detect the development...

    Authors: Xinying Hu, Chao Han, Mingquan Zhang, Jing Jia, Zhengshuai Mu, Zheng Fu, Kailin Qiao, Jinming Yu and Yuchun Wei
    Citation: BMC Cancer 2025 25:854
    Content type: Research Published on:

  50. As the application of Chimeric Antigen Receptor T-cell (CAR-T) therapy in cancer treatment becomes increasingly widespread, associated hematologic and lymphatic system adverse events pose significant challenge...

    Authors: Zhenpo Zhang, Jingping Zheng, Yankun Liang, Qimin Wu, Chufeng Ding, Lin Ma and Ling Su
    Citation: BMC Cancer 2025 25:846
    Content type: Research Published on:

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