Fig. 3

As of the follow-up date from January 1, 2021, to March 1, 2024, among the 21 patients with advanced LUAD harboring EGFR ex20ins mutations, 13 had received prior systemic therapy, while 8 had not. Compared with patients who received prior systemic therapy, those who did not had significantly longer PFS (A), TTF (B), and OS (C). Of the 21 patients, 10 had central nervous system (CNS) metastasis, and 11 did not. Patients without CNS metastasis tended to have prolonged PFS (D), TTF (E), and OS (F) compared to those with CNS metastasis