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Table 5 Univariate analysis in the BCP-ALL patients

From: Autologous stem cell transplantation for adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission. A study by the Acute Leukemia Working Party of the EBMT

 

5 years

 

RI [95% CI]

NRM [95% CI]

LFS [95% CI]

OS [95% CI]

Year of AHSCT

 • 1999 - 2009

53.8% [46–60.9]

5.8% [3–10]

40.4% [33–47.6]

46.6% [38.9–53.9]

 • 2010 - 2020

65.9% [47.6–79.1]

8.7% [2.4–20.2]

25.4% [12.4–40.6]

38.7% [22–55.1]

P value

0.15

0.55

0.08

0.33

Patient age (years)

 • 18–32

55.8% [44.5–65.7]

2.4% [0.4–7.6]

41.8% [31.2–52]

53.6% [42.3–63.6]

 • 32+

56% [47.1–63.9]

9% [4.8–14.7]

35% [27–43.2]

39.6% [30.9–48.1]

P value

0.86

0.12

0.26

0.031

Patient sex

 • Male

56.5% [47.4–64.7]

6.9% [3.4–12.1]

36.6% [28.3–45]

45.1% [36.1–53.7]

 • Female

55.1% [44.3–64.5]

6% [2.2–12.7]

38.9% [28.9–48.8]

44.8% [34–55.1]

P value

0.89

0.33

0.67

0.51

Conditioning:

 • CT-based

55% [46.2–63]

6.7% [3.3–11.8]

38.2% [30–46.4]

45% [36.4–53.3]

 • TBI-based

57.9% [46.4–67.7]

5.8% [2.1–12.3]

36.3% [26.1–46.6]

45.4% [34–56.1]

P value

0.78

0.65

0.92

0.97

Time from diagnosis to AHSCT

 • <median

(6.6 months)

58% [48.7–66.2]

5.7% [2.5–10.8]

36.3% [27.9–44.8]

39.2% [30.4–47.8]

 • >=median

54.6% [43.8–64.1]

7.4% [3.2–13.9]

38.1% [28.1–47.9]

52.6% [41.6–62.5]

P value

0.4

0.92

0.39

0.08

Karnofsky score

 < 90

60.6% [41.3–75.2]

8.1% [2–19.9]

31.3% [16.5–47.3]

38.2% [21.9–54.3]

 >= 90

53.3% [39.8–65.1]

12% [5.1–21.9]

34.7% [22.9–46.9]

42.5% [28.9–55.4]

P value

0.72

0.74

0.78

0.76

  1. RI relapse incidence, NRM non-relapse mortality, LFS leukemia-free survival, OS overall survival, AHSCT autologous hematopoietic stem cell transplantation, ALL acute lymphoblastic leukemia, BCP-ALL B-cell precursor ALL, TCP-ALL T-cell precursor ALL, CT chemotherapy, TBI total body irradiation, CI confidence interval