The impact of CT-based adipose tissue distribution and sarcopenia on treatment outcomes in patients with high-risk soft tissue sarcoma

Table 3 Correlation between body composition parameters and radiologic/pathologic response to treatment

Factor	Strata	Rad. Response (RECIST)		Sig.	Path. Response (EORTC-STBSG)		Sig.
Factor	Strata	PR/SD	PD		A	B-E	Sig.
BMI (kg/m²)	≥ 30	14	3	0.88	1	16	0.35
BMI (kg/m²)	< 30	57	11	0.88	10	58	0.35
SMI (cm²/m²)	Q1	18	4	0.80	1	21	0.20
SMI (cm²/m²)	Q2-Q4	53	10	0.80	10	53	0.20
SMI (cm²/m²)	Male: <52.4* Female: <38.5*	22	6	0.39	2	26	0.28
SMI (cm²/m²)	Male: ≥52.4* Female: ≥38.5*	49	8	0.39	9	48	0.28
TFI (cm²/m²)	Q4	16	5	0.30	3	18	0.83
TFI (cm²/m²)	Q1-Q3	55	9	0.30	8	56	0.83
FMR	Q4	16	5	0.30	2	19	0.59
FMR	Q1-3	55	9	0.30	9	55	0.59
VFI (cm²/m²)	Q4	15	6	0.093	2	19	0.59
VFI (cm²/m²)	Q1-Q3	56	8	0.093	9	55	0.59
SFI (cm²/m²)	Q4	17	4	0.71	2	19	0.59
SFI (cm²/m²)	Q1-Q3	54	10	0.71	9	55	0.59
VSR	Q4	17	4	0.71	4	17	0.34
VSR	Q1-Q3	54	10	0.71	7	57	0.34
MRA (HU)	Q1	19	3	0.68	3	19	0.91
MRA (HU)	Q2-Q4	52	11	0.68	8	55	0.91

BMI = Body mass index, SMI = Skeletal muscle index, TFI = Total fat index, FMR = Total fat to muscle ratio, VFI = Visceral fat index, SFI = Subcutaneous fat index, VSR = Visceral to subcutaneous fat ratio, MRA = Muscle radiation attenuation, HU = Hounsfield units, *=Cut-offs by Prado et al. [30]

ISSN: 1471-2407