Fig. 3
From: Radiotherapy is enhanced by CPH:SA IL-1α microparticles in a murine HNSCC tumor model
IL-1αMPs combined with radiotherapy (RT) induces an anti-tumor response in non-irradiated tumors. HNSCC (mEERL) bilateral tumor‐bearing C57Bl/6 mice (n = 9–10/treatment group) were treated with RT (8 Gy 1X), CPH:SA IL‐1α‐MPs (IL‐1αMPs) or their combination (A). Equivalent doses of Blank MPs were administered to Sham mice as a control. RT was administered to the irradiated tumor on Treatment Day 1 followed by two doses of CPH:SA IL‐1α‐MPs (equivalent to 7.5 μg rIL‐1α in 18.75 mg MPs/ dose) intraperitoneally on Treatment days 2 and 10. Tumor growth of both irradiated (B) and non-irradiated tumors (C) were monitored overtime. D-G: Tumor growth rate of both irradiated and non-irradiated of individual animals in each of the treatment groups are shown in spaghetti plots (D-G). Error bars = SEM. *: p < 0.05, ns: non-significant