Table 1 Cell proliferation inhibition values of BAY-876, niclosamide, IMD-0354, and pyrvinium pamoate. Effective concentration values (µM) where 50% of the cells are not proliferating (EC50) ± SEM of a minimum of three biological replicates. Values were acquired from MTT cell proliferation inhibition assay and SRB cell proliferation inhibition assay against two breast cancer cell lines 4T1 and MDA-MB-231
| Â | 4T1 | MDA-MB-231 | ||
|---|---|---|---|---|
|  | MTT (µM) | SRB (µM) | MTT (µM) | SRB (µM) |
BAY-876 | 0.21 ± 0.02 | 0.13 ± 0.04 | > 100 | 20.47 ± 8.89 |
Niclosamide | 0.30 ± 0.06 | 0.36 ± 0.05 | 4.67 ± 0.99 | 0.87 ± 0.11 |
IMD-0354 | 0.27 ± 0.1 | 0.26 ± 0.09 | 3.43 ± 0.97 | 0.75 ± 0.09 |
Pyrvinium pamoate | 0.034 ± 0.024 | 0.020 ± 0.01 | 0.49 ± 0.05 | 0.15 ± 0.00 |